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24 famotidine COVID-19 controlled studies, 3 RCTs
https://c19early.com/fmmeta.html
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Brennan (DB RCT) 48%
0.52 [0.20-1.32]
no recov.
5/27
10/28
Improvement, RR [CI] Treatment Control Brennan (DB RCT) 43%
0.57 [0.21-1.55]
no recov.
4/19
10/27
Brennan (DB RCT) 28%
0.72 [0.56-0.92]
recov. time
27 (n)
28 (n)
Shoaibi -3%
1.03 [0.89-1.18]
death
1,816 (n)
26,820 (n)
Shoaibi -3%
1.03 [0.92-1.15]
death/ICU
1,816 (n)
26,820 (n)
Zhou (PSM) -81%
1.81 [1.28-2.58]
severe case
72/519
198/2,595
Yeramaneni -59%
1.59 [0.94-2.71]
death
410 (n)
746 (n)
Mura (PSM) 21%
0.79 [0.65-0.96]
death
563 (n)
563 (n)
Mura (PSM) 37%
0.63 [0.47-0.83]
death
305 (n)
305 (n)
Samim.. (SB RCT) 33%
0.67 [0.45-0.98]
hosp. time
10 (n)
10 (n)
Samim.. (SB RCT) 0%
1.00 [0.42-2.40]
no recov.
5/10
5/10
Samim.. (SB RCT) 50%
0.50 [0.17-1.46]
no recov.
3/10
6/10
Elhadi (ICU) 7%
0.93 [0.73-1.17]
death
34/60
247/405
ICU patients
Taşdemir 45%
0.55 [0.20-1.55]
death
5/85
10/94
OT1
Taşdemir 37%
0.63 [0.28-1.43]
ICU
8/85
14/94
OT1
Taşdemir 18%
0.82 [0.72-0.93]
hosp. time
85 (n)
94 (n)
OT1
Taşdemir 20%
0.80 [0.65-0.99]
recov. time
85 (n)
94 (n)
OT1
Kuno (PSM) 0%
1.00 [0.86-1.17]
death
1,593 (n)
7,972 (n)
Stolow -519%
6.19 [2.10-18.3]
death
137 (n)
352 (n)
Stolow -2390%
24.90 [3.70-168]
ICU
137 (n)
352 (n)
Wagner 70%
0.30 [0.20-0.44]
death
638 (n)
819 (n)
Pahwani (RCT) 11%
0.89 [0.36-2.20]
death
8/89
9/89
Pahwani (RCT) 12%
0.88 [0.53-1.45]
ventilation
21/89
24/89
Pahwani (RCT) 10%
0.90 [0.51-1.58]
ICU
18/89
20/89
Pahwani (RCT) 17%
0.83 [0.79-0.89]
hosp. time
89 (n)
89 (n)
Pahwani (RCT) 10%
0.90 [0.85-0.96]
recov. time
89 (n)
89 (n)
Siraj 36%
0.64 [0.48-0.83]
death
183/711
122/289
Zangeneh (ICU) 39%
0.61 [0.42-0.90]
death
n/a
n/a
ICU patients
Freedberg (PSM) 57%
0.43 [0.21-0.86]
death/int.
8/84
332/1,536
Mather (PSM) 61%
0.39 [0.20-0.74]
death
83 (n)
689 (n)
Mather (PSM) 50%
0.49 [0.31-0.79]
death/int.
83 (n)
689 (n)
Balouch 22%
0.78 [0.36-1.51]
symp. case
18/80
49/227
Balouch 37%
0.63 [0.26-1.54]
recov. time
80 (n)
227 (n)
Yeramaneni 51%
0.49 [0.16-1.52]
death
351 (n)
6,807 (n)
Cheung -34%
1.34 [0.24-6.06]
severe case
23 (n)
929 (n)
Fung 0%
1.00 [0.96-1.04]
death
population-based cohort
Fung 6%
0.94 [0.91-0.97]
hosp.
population-based cohort
Fung -12%
1.12 [1.10-1.15]
cases
population-based cohort
Razjouyan 27%
0.73 [0.59-0.92]
death
93 (n)
9,981 (n)
Wallace -11%
1.11 [0.89-1.35]
death
98/423
1,436/7,521
MacFadden 7%
0.93 [0.84-1.03]
cases
n/a
n/a
Loucera 18%
0.82 [0.59-1.15]
death
207 (n)
15,761 (n)
famotidine COVID-19 outcomes c19early.com/fm Oct 2022
1 OT: comparison with other treatment Favors famotidine
Favors control
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