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0 0.5 1 1.5 2+ Mortality 39% Improvement Relative Risk Ventilation 5% Hospitalization time -1% c19mp.com Flisiak et al. Molnupiravir for COVID-19 EARLY Favors molnupiravir Favors control
Flisiak, 590 patient molnupiravir early treatment study: 39% lower mortality [p=0.03], 5% lower ventilation [p=1], and 1% longer hospitalization [p=0.97] https://c19p.org/flisiak2
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Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance.
Flisiak et al., medRxiv, doi:10.1101/2022.07.05.22277227 (Preprint)
6 Jul 2022    Source   PDF   Share   Tweet
Retrospective 590 patients in Poland, 203 treated with mulnupiravir, showing lower mortality with treatment.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom].
risk of death, 39.5% lower, RR 0.61, p = 0.03, treatment 20 of 203 (9.9%), control 63 of 387 (16.3%), NNT 16.
risk of mechanical ventilation, 4.7% lower, RR 0.95, p = 1.00, treatment 7 of 203 (3.4%), control 14 of 387 (3.6%), NNT 591.
hospitalization time, 0.9% higher, relative time 1.01, p = 0.96, treatment mean 11.6 (±7.9) n=203, control mean 11.5 (±9.3) n=387.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Flisiak et al., 7/6/2022, retrospective, Poland, preprint, 13 authors, study period 1 January, 2022 - 30 April, 2022.
Contact: robert.flisiak1@gmail.com.
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