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Home   COVID-19 treatment studies for Tixagevimab/cilgavimab  COVID-19 treatment studies for Tixagev../c..  C19 studies: Tixagev../c..  Tixagev../c..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Symptomatic case, D180 40% Improvement Relative Risk Symptomatic case 33% c19early.com/tc FDA et al. NCT04625972 Tixagev../c.. for COVID-19 RCT Prophylaxis Favors tixagevimab/ci.. Favors control
FDA, 1,121 patient tixagevimab/cilgavimab prophylaxis RCT: 40% fewer symptomatic cases [p=0.07] https://c19p.org/fdatc
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Fact sheet for healthcare providers: emergency use authorization for Evusheld (tixagevimab co-packaged with cilgavimab)
FDA (Preprint)
8 Dec 2021    Source   PDF   Share   Tweet
PEP RCT with 749 tixagevimab/cilgavimab patients and 372 control patients, showing lower risk of symptomatic cases with treatment, without statistical significance. STORM CHASER. NCT04625972.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2 [Zhou].
risk of symptomatic case, 39.5% lower, RR 0.60, p = 0.07, treatment 28 of 749 (3.7%), control 23 of 372 (6.2%), NNT 41, from graph, day 180.
risk of symptomatic case, 32.8% lower, RR 0.67, p = 0.23, treatment 23 of 749 (3.1%), control 17 of 372 (4.6%), NNT 67.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
FDA et al., 12/8/2021, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, multiple regions, preprint, 1 author, trial NCT04625972.
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