Outcomes in COVID-19 ensitrelvir studies
0
0.5
1
1.5+
All studies 45% 1
28
Improvement, Studies, Patients Relative Risk Viral clearance 45% 1
28
RCTs 45% 1
28
Early 45% 1
28
Ensitrelvir for COVID-19 c19early.com/en Jun 2022
Favors ensitrelvir Favors control
0
0.5
1
1.5+
ALL STUDIES
VIRAL CLEARANCE
RCTS
All
Early
Ensitrelvir for COVID-19
C19EARLY.COM/EN JUN 2022
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Mukae (DB RCT) 45%
0.55 [0.37-0.81]
viral load
14 (n)
14 (n)
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Early treatment 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement All studies 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement 1 ensitrelvir COVID-19 study c19early.com/en Jun 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Effect extraction pre-specified (most serious outcome) Favors ensitrelvir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Mukae (DB RCT) 45%
0.55 [0.37-0.81]
viral load
14 (n)
14 (n)
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Early treatment 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement All studies 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement 1 ensitrelvir COVID-19 viral clearance result c19early.com/en Jun 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Favors ensitrelvir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Mukae (DB RCT) 45%
0.55 [0.37-0.81]
viral load
14 (n)
14 (n)
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Early treatment 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement All studies 45%
0.55 [0.37-0.81]
0/14
0/14
45% improvement 1 ensitrelvir COVID-19 Randomized Controlled Trials c19early.com/en Jun 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0025
Effect extraction pre-specified (most serious outcome) Favors ensitrelvir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Mukae (DB RCT) 45%
0.55 [0.37-0.81]
viral load
14 (n)
14 (n)
Improvement, RR [CI] Treatment Control Mukae (DB RCT) 36%
0.64 [0.41-1.00]
viral load
15 (n)
14 (n)
Mukae (DB RCT) 45%
0.55 [0.34-0.90]
viral time
15 (n)
14 (n)
Mukae (DB RCT) 44%
0.56 [0.35-0.92]
viral time
13 (n)
14 (n)
Mukae (DB RCT) 54%
0.46 [0.05-4.38]
viral+
1/12
2/11
Mukae (DB RCT) -10%
1.10 [0.22-5.51]
viral+
3/15
2/11
Mukae (DB RCT) 80%
0.20 [0.01-3.80]
viral+
0/13
2/13
Mukae (DB RCT) 54%
0.46 [0.05-4.53]
viral+
1/14
2/13
Mukae (DB RCT) 54%
0.46 [0.10-2.12]
viral+
2/14
4/13
Mukae (DB RCT) 90%
0.10 [0.01-1.77]
viral+
0/15
4/13
Mukae (DB RCT) 80%
0.20 [0.05-0.75]
viral+
2/14
10/14
Mukae (DB RCT) 63%
0.37 [0.15-0.92]
viral+
4/15
10/14
Mukae (DB RCT) 9%
0.91 [0.59-1.40]
viral+
10/14
11/14
Mukae (DB RCT) -10%
1.10 [0.79-1.55]
viral+
13/15
11/14
ensitrelvir COVID-19 outcomes c19early.com/en Jun 2022
Favors ensitrelvir
Favors control
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treatments are both valuable and complementary. All practical, effective, and
safe means should be used. No treatment, vaccine, or intervention is 100%
available and effective for all current and future variants. Denying the
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the risk of endemic status. We do not provide medical advice. Before taking
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