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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.0025 Early treatment 45% 0.55 [0.37-0.81] 0/14 0/14 45% improvement All studies 45% 0.55 [0.37-0.81] 0/14 0/14 45% improvement 1 ensitrelvir COVID-19 study c19early.com/en Jun 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.0025 Effect extraction pre-specified(most serious outcome) Favors ensitrelvir Favors control
Ensitrelvir COVID-19 studies. Recent:
Mukae.
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May 17
Early Mukae et al., medRxiv, doi:10.1101/2022.05.17.22275027 (Preprint)
viral load, ↓45.2%, p=0.002
A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-like Protease Inhibitor, in Japanese Patients With Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part
Details   RCT 69 patients in in Japan, showing faster viral clearance with ensitrelvir. 5-day ensitrelvir (375mg on day 1 followed by 125 mg daily or 750mg on day 1 followed by 250mg daily).
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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