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0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk ICU admission 67% Recovery time 35% Time to viral- 44% c19early.com/va Elkazzaz et al. NCT04353180 Vitamin A RCT LATE TREATMENT Favors vitamin A Favors control
Elkazzaz, 40 patient vitamin A late treatment RCT: 86% lower mortality [p=0.23], 67% lower ICU admission [p=0.24], 35% faster recovery [p<0.0001], and 44% faster viral clearance [p<0.0001] https://c19p.org/elkazzaz
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13 cis retinoic acid improved the outcomes of COVID-19 patients. A randomized clinical trial
Elkazzaz et al., medRxiv, doi:10.1101/2022.03.05.22271959 (Preprint), NCT04353180 (history)
8 Mar 2022    Source   PDF   Share   Tweet
RCT with 20 13-cis-retinoic acid patients and 20 control patients, showing faster recovery and viral clearance with treatment. Aerosolized 13-cis-retinoic acid with increasing dose from 0.2 mg/kg/day to 4 mg/kg/day for 14 days, plus oral 13-cis-retinoic acid 20 mg/day. 13-cis retinoic acid is a synthetic vitamin A derivative, and is teratogenic. NCT04353180 (history).
risk of death, 85.7% lower, RR 0.14, p = 0.23, treatment 0 of 20 (0.0%), control 3 of 20 (15.0%), NNT 6.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 66.7% lower, RR 0.33, p = 0.24, treatment 2 of 20 (10.0%), control 6 of 20 (30.0%), NNT 5.0.
recovery time, 35.4% lower, relative time 0.65, p < 0.001, treatment mean 16.3 (±4.5) n=20, control mean 25.23 (±4.72) n=20.
time to viral-, 44.0% lower, relative time 0.56, p < 0.001, treatment mean 13.36 (±1.49) n=20, control mean 23.85 (±4.0) n=20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Elkazzaz et al., 8 Mar 2022, Randomized Controlled Trial, Egypt, preprint, 4 authors, study period June 2020 - August 2020, trial NCT04353180 (history).
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Late treatment
is less effective
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