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0 0.5 1 1.5 2+ Mortality 72% Improvement Relative Risk Hospitalization 43% Hospitalization/ER 51% c19early.com/il Eiger BioPharmaceuticals et al. NCT04727424 Peg.. Lambda RCT EARLY Favors peg.. lambda Favors control
Eiger BioPharmaceuticals, 1,936 patient peginterferon lambda early treatment RCT: 72% lower mortality [p=0.38], 43% lower hospitalization [p=0.04], and 51% fewer combined hospitalization/ER visits [p=0.002] https://c19p.org/eigeril
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Eiger's Single-dose Peginterferon Lambda for COVID-19 Reduced Risk of Hospitalization or ER Visits by 50% in a Predominantly Vaccinated Population in Phase 3 TOGETHER Study
Eiger BioPharmaceuticals (Preprint), NCT04727424 (history)
17 Mar 2022    Source   PDF   Share   Tweet
High-risk outpatient RCT with 916 peginterferon lambda patients and 1,020 control patients, showing significantly lower hospitalization/ER visits with treatment. Single subcutaneous injection.
For more discussion see [twitter.com].
risk of death, 72.2% lower, RR 0.28, p = 0.38, treatment 1 of 916 (0.1%), control 4 of 1,020 (0.4%), NNT 353.
risk of hospitalization, 43.0% lower, RR 0.57, p = 0.04, treatment 21 of 916 (2.3%), control 41 of 1,020 (4.0%), NNT 58.
risk of hospitalization/ER, 51.2% lower, RR 0.49, p = 0.002, treatment 25 of 916 (2.7%), control 57 of 1,020 (5.6%), NNT 35.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Eiger BioPharmaceuticals et al., 17 Mar 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, preprint, 1 author, trial NCT04727424 (history).
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