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0 0.5 1 1.5 2+ Hospitalization -50% Improvement Relative Risk Case -43% Case (b) 8% c19hcq.com de la Iglesia et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
de la Iglesia, 1,375 patient HCQ prophylaxis study: 43% more cases [p=0.15] https://c19p.org/delaiglesia
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Hydroxicloroquine for pre-exposure prophyylaxis for SARS-CoV-2
de la Iglesia et al., medRxiv, doi:10.1101/2020.08.31.20185314 (Preprint)
2 Sep 2020    Source   PDF   Share   Tweet
Analysis of autoimmune disease patients on HCQ, compared to a control group from the general population (matched on age and sex, but not adjusted for autoimmune disease), showing non-significant differences between groups.
Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [Ferri], which is the observed real-world risk, taking into account factors such as these patients potentially being more careful to avoid exposure.
If we adjust for the different baseline risk, the mortality result becomes RR 0.35, p=0.23, suggesting a substantial benefit for HCQ treatment (as shown in other studies).
risk of hospitalization, 50.0% higher, RR 1.50, p = 1.00, treatment 3 of 687 (0.4%), control 2 of 688 (0.3%).
risk of case, 42.6% higher, RR 1.43, p = 0.15, treatment 42 of 648 (6.5%), control 30 of 660 (4.5%), suspected COVID-19.
risk of case, 7.8% lower, RR 0.92, p = 0.84, treatment 12 of 678 (1.8%), control 13 of 677 (1.9%), NNT 665, confirmed COVID-19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients.
de la Iglesia et al., 9/2/2020, retrospective, database analysis, Spain, Europe, preprint, 17 authors.
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