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0 0.5 1 1.5 2+ Mortality -3% Improvement Relative Risk Ventilation -16% ICU admission 9% ICU time -12% Hospitalization time -10% c19early.com/na de Alencar et al. N-acetylcys.. for COVID-19 RCT LATE Favors N-acetylcysteine Favors control
de Alencar, 135 patient N-acetylcysteine late treatment RCT: 3% higher mortality [p=0.94], 16% higher ventilation [p=0.64], 9% lower ICU admission [p=0.65], and 10% longer hospitalization [p=0.87] https://c19p.org/dealencar
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Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19)
de Alencar et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa1443
23 Sep 2020    Source   PDF   Share   Tweet
RCT 135 severe stage patients in Brazil, showing no significant differences. NAC 21g (~300mg/kg) for 20 hours. U1111-1250-356 [ensaiosclinicos.gov.br].
risk of death, 2.6% higher, RR 1.03, p = 0.94, treatment 9 of 67 (13.4%), control 9 of 68 (13.2%), odds ratio converted to relative risk.
risk of mechanical ventilation, 16.0% higher, RR 1.16, p = 0.64, treatment 16 of 67 (23.9%), control 14 of 68 (20.6%), odds ratio converted to relative risk.
risk of ICU admission, 8.5% lower, RR 0.91, p = 0.65, treatment 29 of 67 (43.3%), control 32 of 68 (47.1%), NNT 26, odds ratio converted to relative risk.
ICU time, 12.5% higher, relative time 1.12, p = 0.56, treatment 67, control 68.
hospitalization time, 10.0% higher, relative time 1.10, p = 0.87, treatment 67, control 68.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
de Alencar et al., 9/23/2020, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, South America, peer-reviewed, median age 59.0, 65 authors, average treatment delay 7.0 days.
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Late treatment
is less effective
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