de Alencar, 135 patient N-acetylcysteine late treatment RCT: 3% higher mortality [p=0.94], 16% higher ventilation [p=0.64], 9% lower ICU admission [p=0.65], and 10% longer hospitalization [p=0.87] https://c19p.org/dealencar
copied to clipboard
Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19)
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa1443
RCT 135 severe stage patients in Brazil, showing no significant differences. NAC 21g (~300mg/kg) for 20 hours. U1111-1250-356 [ensaiosclinicos.gov.br].
|
risk of death, 2.6% higher, RR 1.03, p = 0.94, treatment 9 of 67 (13.4%), control 9 of 68 (13.2%), odds ratio converted to relative risk.
|
|
risk of mechanical ventilation, 16.0% higher, RR 1.16, p = 0.64, treatment 16 of 67 (23.9%), control 14 of 68 (20.6%), odds ratio converted to relative risk.
|
|
risk of ICU admission, 8.5% lower, RR 0.91, p = 0.65, treatment 29 of 67 (43.3%), control 32 of 68 (47.1%), NNT 26, odds ratio converted to relative risk.
|
|
ICU time, 12.5% higher, relative time 1.12, p = 0.56, treatment 67, control 68.
|
|
hospitalization time, 10.0% higher, relative time 1.10, p = 0.87, treatment 67, control 68.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
de Alencar et al., 9/23/2020, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, South America, peer-reviewed, median age 59.0, 65 authors, average treatment delay 7.0 days.
Late treatment
is less effective
is less effective
Please send us corrections, updates, or comments. Vaccines and
treatments are both valuable and complementary. All practical, effective, and
safe means should be used. No treatment, vaccine, or intervention is 100%
available and effective for all current and future variants. Denying the
efficacy of any method increases mortality, morbidity, collateral damage, and
the risk of endemic status. We do not provide medical advice. Before taking
any medication, consult a qualified physician who can provide personalized
advice and details of risks and benefits based on your medical history and
situation. FLCCC and WCH
provide treatment protocols.