Davarpanah, 206 patient spironolactone antiandrogen late treatment study: 78% lower hospitalization [p=0.0008] and 64% faster recovery [p=0.0001] https://c19p.org/davarpanah
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Combination of Spironolactone and Sitagliptin Improves Clinical Outcomes of Outpatients with COVID-19: An Observational Study
et al., medRxiv, doi:10.1101/2022.01.21.22269322 (Preprint)
Prospective study of 206 outpatients in Iran, 103 treated with spironolactone and sitagliptin, showing lower hospitalization and faster recovery with treatment. spironolactone 100mg and sitagliptin 100mg daily.
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risk of hospitalization, 78.3% lower, RR 0.22, p < 0.001, treatment 6 of 103 (5.8%), control 23 of 103 (22.3%), NNT 6.1, odds ratio converted to relative risk.
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recovery time, 64.4% lower, relative time 0.36, p < 0.001, treatment 103, control 103.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Davarpanah et al., 1/21/2022, prospective, Iran, Middle East, preprint, 9 authors, study period July 2021 - September 2021, average treatment delay 5.74 days, this trial uses multiple treatments in the treatment arm (combined with sitagliptin) - results of individual treatments may vary.
Late treatment
is less effective
is less effective
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