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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk c19early.com/mf Crouse et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Crouse, 220 patient metformin prophylaxis study: 61% lower mortality [p=0.02] https://c19p.org/crouse
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Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes
Crouse et al., Front. Endocrinol., doi:10.3389/fendo.2020.600439
13 Jan 2021    Source   PDF   Share   Tweet
Retrospective 219 COVID-19+ diabetes patients in the USA, showing lower mortality with existing metformin treatment.
risk of death, 60.8% lower, RR 0.39, p = 0.02, treatment 8 of 76 (10.5%), control 34 of 144 (23.6%), NNT 7.6, adjusted per study, odds ratio converted to relative risk, multiple logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Crouse et al., 1/13/2021, retrospective, USA, North America, peer-reviewed, 6 authors.
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