Outcomes in COVID-19 convalescent plasma studies
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.07] 1,642/7,089 1,564/6,621 -0% improvement All studies -1% 1.01 [0.90-1.13] 1,654/7,447 1,571/6,979 -1% improvement 13 convalescent plasma COVID-19 studies c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 6.8%; Z = 0.18 Effect extraction pre-specified Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.07] 1,642/7,089 1,564/6,621 -0% improvement All studies -1% 1.01 [0.90-1.13] 1,654/7,447 1,571/6,979 -1% improvement 13 convalescent plasma COVID-19 mortality results c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 6.8%; Z = 0.18 Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 67% 0.33 [0.07-1.60] 2/80 6/80 Improvement, RR [CI] Treatment Control Tau2 = 0.00; I2 = 0.0% Early treatment 67% 0.33 [0.07-1.60] 2/80 6/80 67% improvement All studies 67% 0.33 [0.07-1.59] 2/80 6/80 67% improvement 1 convalescent plasma COVID-19 ICU result c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 0.0%; Z = 1.38 Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Improvement, RR [CI] Treatment Control Tau2 = 0.00; I2 = 0.0% Early treatment 10% 0.90 [0.64-1.26] 51/257 56/254 10% improvement Bajpai (RCT) 25% 0.75 [0.55-1.04] hosp. time 14 (n) 15 (n) Improvement, RR [CI] Treatment Control AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Tau2 = 0.00; I2 = 0.0% Late treatment 23% 0.77 [0.61-0.96] 0/34 0/35 23% improvement All studies 19% 0.81 [0.67-0.97] 51/291 56/289 19% improvement 3 convalescent plasma COVID-19 hospitalization results c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 0.0%; Z = 2.28 Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.07] 1,642/7,089 1,564/6,621 -0% improvement All studies -1% 1.01 [0.90-1.13] 1,654/7,447 1,571/6,979 -1% improvement 13 convalescent plasma COVID-19 serious outcomes c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 6.8%; Z = 0.18 Effect extraction pre-specified Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Improvement, RR [CI] Treatment Control Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 Bajpai (RCT) 32% 0.68 [0.42-1.09] viral load 14 (n) 15 (n) Tau2 = 0.09; I2 = 59.2% Late treatment 41% 0.59 [0.37-0.92] 60/213 91/207 41% improvement All studies 41% 0.59 [0.37-0.92] 60/213 91/207 41% improvement 3 convalescent plasma COVID-19 viral clearance results c19early.com/cp Sep 24, 2021 Tau2 = 0.09; I2 = 59.2%; Z = 2.31 Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.07] 1,642/7,089 1,564/6,621 -0% improvement All studies -1% 1.01 [0.90-1.13] 1,654/7,447 1,571/6,979 -1% improvement 13 convalescent plasma COVID-19 Randomized Controlled Trials c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 6.8%; Z = 0.18 Effect extraction pre-specified Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.07] 1,642/7,089 1,564/6,621 -0% improvement All studies -1% 1.01 [0.90-1.13] 1,654/7,447 1,571/6,979 -1% improvement 13 convalescent plasma COVID-19 RCT mortality results c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 6.8%; Z = 0.18 Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Tau2 = 0.74; I2 = 47.5% Early treatment -93% 1.93 [0.47-7.87] 12/358 7/358 -93% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Tau2 = 0.00; I2 = 0.0% Late treatment -0% 1.00 [0.94-1.06] 1,639/7,075 1,563/6,606 -0% improvement All studies -0% 1.00 [0.93-1.08] 1,651/7,433 1,570/6,964 -0% improvement 12 convalescent plasma COVID-19 peer reviewed trials c19early.com/cp Sep 24, 2021 Tau2 = 0.00; I2 = 1.3%; Z = 0.12 Effect extraction pre-specified Favors conv. plasma Favors control
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Libster (DB RCT) 50% 0.50 [0.09-2.65] ventilation 2/80 4/80 Libster (DB RCT) 67% 0.33 [0.07-1.60] ICU 2/80 6/80 Libster (DB RCT) 48% 0.52 [0.29-0.94] progression 13/80 25/80 Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Balcells (RCT) -163% 2.63 [0.43-9.10] ventilation 5/28 2/30 Balcells (RCT) -23% 1.23 [0.56-1.89] progression 13/28 12/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Korley (RCT) 6% 0.94 [0.72-1.22] progression 77/257 81/254 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Li (RCT) 15% 0.85 [0.53-1.18] no improv. 25/52 29/51 Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Avendaño-Solà (RCT) 93% 0.07 [0.00-1.19] progression 0/38 7/43 Avendaño-Solà (RCT) 92% 0.08 [0.00-1.40] progression 0/38 6/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Agarwal (RCT) -7% 1.07 [0.73-1.58] progression 44/235 41/229 Agarwal (RCT) 1% 0.99 [0.54-1.81] ventilation 19/227 19/224 Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 Bajpai (RCT) -114% 2.14 [0.22-21.1] death 2/14 1/15 Bajpai (RCT) -221% 3.21 [0.38-27.4] ventilation 3/14 1/15 Bajpai (RCT) 25% 0.75 [0.55-1.04] hosp. time 14 (n) 15 (n) Bajpai (RCT) 32% 0.68 [0.42-1.09] viral load 14 (n) 15 (n) AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 AlQahtani (RCT) 33% 0.67 [0.22-2.01] ventilation 4/20 6/20 AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Simonovich (RCT) 19% 0.81 [0.50-1.31] 7-point status 228 (n) 105 (n) Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Bégin (RCT) -12% 1.12 [0.86-1.46] death 141/614 63/307 Bégin (RCT) -16% 1.16 [0.94-1.43] int./death 199/614 86/307 convalescent plasma COVID-19 outcomes c19early.com/cp Sep 24, 2021 Favors conv. plasma Favors control
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