Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Raad -240% 3.40 [2.29-5.02] death 284 (n) 3,682 (n) Tau​2 = 0.14, I​2 = 75.9%, p = 0.57 Late treatment -10% 1.10 [0.81-1.49] 1,642/7,965 1,567/10,892 -10% improvement All studies -12% 1.12 [0.84-1.50] 1,655/8,718 1,577/11,647 -12% improvement 17 convalescent plasma COVID-19 studies Sep 2022 Tau​2 = 0.14, I​2 = 69.2%, p = 0.46 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control
Convalescent Plasma COVID-19 studies. Recent:
Convalescent Plasma has been officially adopted for early treatment in 1 country. Submit updates/corrections.
Aug 26
Late Raad et al., medRxiv, doi:10.1101/2022.08.25.22279181 (Preprint)
death, ↑240.0%, p<0.0001
International Multicenter Study Comparing Cancer to Non-Cancer Patients with COVID-19: Impact of Risk Factors and Treatment Modalities on Survivorship
Details   Retrospective 3,966 COVID-19 patients, 1,115 with cancer, showing lower mortality with remdesivir and higher mortality with convalescent plasma.
Aug 23
Early Gharbharan et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2022.08.005
death, ↑1.0%, p=1.00
Outpatient convalescent plasma therapy for high-risk patients with early COVID-19. A randomized placebo-controlled trial
Details   RCT 416 outpatients in the Netherlands, showing no significant difference with convalesent plasma treatment. Hospitalization was lower, and improved results were seen with ≤5 days of symptoms, without statistical significance.
Feb 9
Early Alemany et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00545-2
death, ↓80.0%, p=0.50
High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial
Details   RCT 188 convalescent plasma and 188 control patients, showing no significant difference in outcomes.
Dec 21
Late Sullivan et al., New England Journal of Medicine, doi:10.1056/NEJMoa2119657 (preprint 12/21/2021)
death, ↓85.7%, p=0.12
Early Outpatient Treatment for Covid-19 with Convalescent Plasma
Details   RCT 1,181 outpatients in the USA, mean 6 days from symptom onset, showing lower hospitalization with treatment. NCT04373460.
Sep 9
Late Bégin et al., Nature Medicine, doi:10.1038/s41591-021-01488-2
death, ↑13.0%, p=0.33
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial
Details   RCT 940 hospitalized patients, 614 assigned to convalescent plasma, showing no significant differences. NCT04348656.
Aug 18
Early Korley et al., NEJM, doi:10.1056/NEJMoa2103784
death, ↑396.0%, p=0.22
Early Convalescent Plasma for High-Risk Outpatients with Covid-19
Details   RCT 511 emergency department patients, 257 assigned to convalescent plasma, showing no significant difference in outcomes.
Mar 3
Early Balcells et al., PLOS Medicine, doi:10.1371/journal.pmed.1003415
death, ↑247.4%, p=0.17
Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
Details   Small RCT with 28 early and 30 deferred (treated according to prespecified deterioration criteria) convalescent plasma patients, not showing significant differences. "Early" is relative, with a median of 5 days from symptom onse..
Jan 15
Late Recovery Collaborative Group, The Lancet, doi:10.1016/S0140-6736(21)00897-7 (press release 1/15/2021)
death, 0.0%, p=0.95
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Details   RCT 16,287 hospitalized patients in the UK, showing no significant differences with convalescent plasma treatment. Subgroup analysis shows better results for those treated <= 7 days from symptom onset.
Jan 6
Early Libster et al., NEJM, doi:10.1056/NEJMoa2033700
death, ↓50.0%, p=0.43
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Details   RCT 160 patients >=65 with symptom onset <72 hours, 80 treated with convalescent plasma, showing lower progression to severe disease with treatment. NCT04479163.
Nov 29
Late Ray et al., medRxiv, doi:10.1101/2020.11.25.20237883
death, ↓33.0%, p=0.34
Clinical and immunological benefits of convalescent plasma therapy in severe COVID-19: insights from a single center open label randomised control trial
Details   Small RCT 80 hospitalized patients in India, 40 treated with convalescent plasma, not showing significant differences in primary analysis. Authors note that significant improvement in hypoxia, reduction in hospital stay, and survival bene..
Nov 24
Late Simonovich et al., NEJM, doi:0.1056/NEJMoa2031304
death, ↓4.1%, p=1.00
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
Details   RCT 333 hospitalized patients in Argentina, 228 treated with convalescent plasma, showing no significant differences in clinical status or mortality. NCT04383535.
Nov 4
Late AlQahtani et al., Scientific Reports, doi:10.1038/s41598-021-89444-5 (preprint 11/4/2020)
death, ↓50.0%, p=0.55
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease
Details   Small RCT with 40 hospitalized patients in Bahrain, 20 treated with convalescent plasma, not showing significant differences. NCT04356534.
Oct 27
Late Bajpai et al., medRxiv, doi:10.1101/2020.10.25.20219337 (Preprint)
death, ↑323.0%, p=0.22
Efficacy of Convalescent Plasma Therapy compared to Fresh Frozen Plasma in Severely ill COVID-19 Patients: A Pilot Randomized Controlled Trial
Details   Small RCT 29 patients in India, 14 treated with convalescent plasma, not showing significant differences with treatment.
Oct 22
Late Agarwal et al., BMJ, doi:10.1136/bmj.m3939
death, ↑7.0%, p=0.74
Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)
Details   RCT 464 hospitalized patients in India, 235 treated with convalescent plasma, showing no improvement in combined death at 28 days or progression to severe disease. CTRI/2020/04/024775.
Sep 29
Late Avendaño-Solà et al., medRxiv, doi:10.1101/2020.08.26.20182444
death, ↓88.3%, p=0.12
Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Details   Early terminated RCT with 81 hospitalized patients, 38 treated with convalescent plasma, showing lower progression with treatment. NCT04345523.
Jun 3
Late Li et al., JAMA, doi:10.1001/jama.2020.10044
death, ↓34.6%, p=0.30
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial
Details   Small RCT 103 severe condition patients, 52 treated with convalescent plasma, showing improved viral clearance but no statistically significant improvements in mortality or clinical improvement. ChiCTR2000029757.
May 27
Late Gharbharan et al., Nature Communications, doi:10.1038/s41467-021-23469-2
death, ↓3.8%, p=0.95
Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection
Details   RCT 86 hospitalized patients, 43 treated with convalescent plasma, showing no significant differences with treatment. Authors conclude that the most likely explanation was already high antibody titers on the day of inclusion, and they rec..
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