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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -65% Improvement Relative Risk c19early.com/cheng2.html Favors metformin Favors control
20 August 2021 - Prophylaxis study
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
Cheng et al., Cell Metabolism, doi:10.1016/j.cmet.2020.08.013 (Peer Reviewed)
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Retrospective 1,213 hospitalized diabetic COVID-19 patients in China, showing no significant difference in mortality with pre-existing metformin use.
risk of death, 65.0% higher, RR 1.65, p = 0.25, treatment 678, control 535, after PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Cheng et al., 8/20/2021, retrospective, propensity score matching, China, Asia, peer-reviewed, 35 authors.
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