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Metformin study #3 of 7   All Outcomes
7/31 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Chen et al., Diabetes Care, doi:10.2337/dc20-0660 (Peer Reviewed)
Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication
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Retrospective 120 COVID-19 diabetes patients, showing non-statistically significantly lower mortality with existing metformin treatment.
Chen et al., 7/31/2020, retrospective, China, Asia, peer-reviewed, 12 authors.
risk of death, 33.0% lower, RR 0.67, p = 0.46, treatment 4 of 43 (9.3%), control 15 of 77 (19.5%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 7 studies   All Outcomes
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