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0 0.5 1 1.5 2+ Mortality -54% Improvement Relative Risk Ventilation -27% c19early.com/no Chandel et al. Nitric Oxide for COVID-19 LATE Favors nitric oxide Favors control
Chandel, 272 patient nitric oxide late treatment study: 54% higher mortality [p=0.25] and 27% higher ventilation [p=0.26] https://c19p.org/chandel
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Inhaled Nitric Oxide via High-Flow Nasal Cannula in Patients with Acute Respiratory Failure Related to COVID-19
Chandel et al., Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, doi:10.1177/11795484211047065
31 Jan 2021    Source   PDF   Share   Tweet
Retrospective 272 acute respitory failure patients in the USA treated with high-flow nasal cannula, 66 treated with inhaled nitric oxide, showing increased mortality with inhaled nitric oxide. There were significant differences in the usage of several other treatments between the groups.
risk of death, 54.1% higher, RR 1.54, p = 0.25, treatment 12 of 66 (18.2%), control 36 of 206 (17.5%), adjusted per study, odds ratio converted to relative risk, multivariable.
risk of mechanical ventilation, 27.2% higher, RR 1.27, p = 0.26, treatment 29 of 66 (43.9%), control 79 of 206 (38.3%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chandel et al., 1/31/2021, retrospective, USA, peer-reviewed, 14 authors, study period 1 March, 2020 - 9 June, 2020.
Contact: abhimanyu.chandel.mil@mail.mil.
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