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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -18% Improvement Relative Risk Case -27% c19early.com/ace Chandan et al. Acetaminophen for COVID-19 Prophylaxis Favors acetaminophen Favors NSAIDs
Chandan, 17,190 patient acetaminophen prophylaxis PSM study: 18% higher mortality [p=0.35] and 27% more cases [p=0.17] https://c19p.org/chandan
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Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID‐19
Chandan et al., Arthritis & Rheumatology, doi:10.1002/art.41593
29 Apr 2021    Source   PDF   Share   Tweet
Retrospective 12,457 patients prescribed paracetamol with codeine/dihydrocodeine and 13,202 prescribed NSAIDs, showing no significant differences in cases and mortality. Patients prescribed codeine/dihydrocodeine may have different susceptibility to COVID-19.
risk of death, 17.6% higher, HR 1.18, p = 0.35, treatment 8,595, control 8,595, adjusted per study, inverted to make RR<1 favor treatment, propensity score matching, multivariable.
risk of case, 26.6% higher, HR 1.27, p = 0.17, treatment 8,595, control 8,595, adjusted per study, inverted to make RR<1 favor treatment, propensity score matching, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chandan et al., 29 Apr 2021, retrospective, United Kingdom, peer-reviewed, mean age 65.4, 24 authors, study period 30 January, 2020 - 31 July, 2020, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with codeine or dihydrocodeine) - results of individual treatments may vary.
Contact: k.nirantharan@bham.ac.uk, k.raza@bham.ac.uk.
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