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Cannabidiol COVID-19 studies. Submit updates/corrections.
May 20
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
meta-analysis
Cannabidiol for COVID-19: real-time meta analysis of 3 studies
Details   • Meta analysis using the most serious outcome reported shows 53% [-68‑616%] higher risk, without reaching statistical significance. • While non-symptomatic case results show 32% [-6‑57%] improvement, symptomatic res..
Mar 8
PrEPPEP Huang et al., Frontiers in Public Health, doi:10.3389/fpubh.2022.829715
death, ↑181.0%, p=0.04
Cannabis use is associated with lower COVID-19 susceptibility but poorer survival
Details   UK Biobank retrospective with 13,099 cannabis users, showing a lower risk of COVID-19 infection, however regular users had a significantly higher risk of mortality.
Jan 20
PrEPPEP Nguyen et al., Science Advances, doi:10.1126/sciadv.abi6110 (preprint 3/10/2021)
cases, ↓49.6%, p=0.006
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
Details   Retrospective 1,212 patients in the USA with a history of seizure-related conditions, showing patients treated with CBD100 had significantly lower incidence of COVID-19 cases compared to a matched control group. In Vitro study showing CBD..
Jan 10
In Vitro van Breemen et al., Journal of Natural Products, doi:10.1021/acs.jnatprod.1c00946 (In Vitro)
In Vitro
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
Details   In Vitro study showing that cannabigerolic acid and cannabidiolic acid inhibited SARS-CoV-2 entry into cells.
Oct 7
2021
Late Crippa et al., Cannabis and Cannabinoid Research, doi:10.1089/can.2021.0093
hosp., ↑557.1%, p=0.25
Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Details   RCT 105 patients recruited in an ER in Brazil, 49 treated with CBD, showing no significant differences with treatment. 300mg CBD for 14 days. For discussion see .
Feb 17
2021
Review Malinowska et al., International Journal of Molecular Sciences, doi:10.3390/ijms22041986 (Review)
review
Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19
Details   Review of the potential benefits and concerns for the use of cannabidiol in the treatment of COVID-19.
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
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