Statistically significant lower risk is seen for cases and viral clearance. 5 studies from 4 independent teams in 4 countries show statistically significant improvements.
Meta analysis using the most serious outcome reported shows 27% [-8‑50%] lower risk, without reaching statistical significance. Results are similar for Randomized Controlled Trials and worse for peer-reviewed studies. Early treatment shows efficacy while late treatment does not, consistent with expectations for an effective topical nasopharyngeal/oropharyngeal treatment.
Mortality results are negative, however all results to date are from late treatment trials.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments are more effective. Nitric Oxide may affect the natural microbiome, especially with prolonged use.
All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., Apr 2024, preprint, 1 author.
