Statistically significant lower risk is seen for recovery. 2 studies (both from the same team) show statistically significant improvements.
Meta analysis using the most serious outcome reported shows 74% [-20‑94%] lower risk, without reaching statistical significance. Results are worse for Randomized Controlled Trials.
Currently there is limited data, with only 605 patients in trials to date. Studies to date are from only 3 different groups.
Concerns have been raised over potential harm with the use of NSAIDs for COVID-19 due to the suppression of beneficial immune and inflammatory responses during early infection, and delaying further care. There are currently no early treatment studies for indomethacin. Early treatment results for NSAID ibuprofen suggest higher risk. Indomethacin may be beneficial for cough Alkotaji, which may not respond to other treatments.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. There has been no early treatment studies to date.
All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., Apr 2024, preprint, 1 author.
