Outcomes in COVID-19 bebtelovimab studies
0
0.5
1
1.5+
ALL STUDIES
MORTALITY
HOSPITALIZATION
VIRAL CLEARANCE
RCTS
All
Early
Bebtelovimab for COVID-19
C19EARLY.COM/BT MAY 2022
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 study c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 mortality result c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -27%
1.27 [0.25-6.46]
hosp.
5/252
2/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.79
Early treatment -27%
1.27 [0.25-6.46]
5/252
2/128
-27% improvement All studies -27%
1.27 [0.25-6.46]
5/252
2/128
-27% improvement 1 bebtelovimab COVID-19 hospitalization result c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.79
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 serious outcome c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) 36%
0.64 [0.40-1.03]
viral+
33/252
26/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.066
Early treatment 36%
0.64 [0.40-1.03]
33/252
26/128
36% improvement All studies 36%
0.64 [0.40-1.03]
33/252
26/128
36% improvement 1 bebtelovimab COVID-19 viral clearance result c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.066
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 Randomized Controlled Trials c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 RCT mortality result c19early.com/bt May 2022
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Lilly (RCT) -201%
3.01 [0.12-73.2]
death
1/127
0/128
Lilly (RCT) -27%
1.27 [0.25-6.46]
hosp.
5/252
2/128
Lilly (RCT) -51%
1.51 [0.26-8.90]
hosp.
3/127
2/128
Lilly (RCT) -2%
1.02 [0.15-7.16]
hosp.
2/125
2/128
Lilly (RCT) 36%
0.64 [0.40-1.03]
viral+
33/252
26/128
Lilly (RCT) 38%
0.62 [0.35-1.10]
viral+
16/127
26/128
Lilly (RCT) 33%
0.67 [0.38-1.17]
viral+
17/125
26/128
bebtelovimab COVID-19 outcomes c19early.com/bt May 2022
Favors bebtelovimab
Favors control
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