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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 7% Improvement Relative Risk Mortality (b) 24% Mortality (c) -3% c19early.com/bramante.html Favors metformin Favors control
3 December 2020 - Prophylaxis study
Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis
Bramante et al., The Lancet Healthy Longevity, doi:10.1016/S2666-7568(20)30033-7 (Peer Reviewed)
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Retrospective 6,256 COVID-19+ diabetes patients in the USA, showing lower mortality with existing metformin treatment, statistically significant only for women.
risk of death, 7.2% lower, RR 0.93, p = 0.15, treatment 394 of 2,333 (16.9%), control 791 of 3,923 (20.2%), NNT 31, odds ratio converted to relative risk, PSM, all patients.
risk of death, 24.1% lower, RR 0.76, p = 0.02, treatment 1,129, control 2,173, PSM, women, RR approximated with OR.
risk of death, 3.5% higher, RR 1.03, p = 0.75, treatment 1,204, control 1,750, PSM, men, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Bramante et al., 12/3/2020, retrospective, database analysis, USA, North America, peer-reviewed, 17 authors.
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