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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 10% Improvement Relative Risk c19early.com/boye.html Favors metformin Favors control
18 July 2021 - Prophylaxis study
Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States
Boye et al., Diabetes Therapy, doi:10.1007/s13300-021-01110-1 (Peer Reviewed)
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Retrospective 9531 COVID+ diabetes patients in the USA, showing lower risk of hospitalization with existing biguanides treatment (defined as mainly metformin in the abstract and entirely metformin in the text).
risk of hospitalization, 10.0% lower, RR 0.90, p < 0.001, treatment 2,067 of 4,250 (48.6%), control 3,196 of 5,281 (60.5%), NNT 8.4, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Boye et al., 7/18/2021, retrospective, USA, North America, peer-reviewed, 14 authors.
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