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0 0.5 1 1.5 2+ Hospitalization 10% Improvement Relative Risk c19early.com/mf Boye et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Boye, 9,531 patient metformin prophylaxis study: 10% lower hospitalization [p<0.0001] https://c19p.org/boye
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Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States
Boye et al., Diabetes Therapy, doi:10.1007/s13300-021-01110-1
18 Jul 2021    Source   PDF   Share   Tweet
Retrospective 9531 COVID+ diabetes patients in the USA, showing lower risk of hospitalization with existing biguanides treatment (defined as mainly metformin in the abstract and entirely metformin in the text).
risk of hospitalization, 10.0% lower, RR 0.90, p < 0.001, treatment 2,067 of 4,250 (48.6%), control 3,196 of 5,281 (60.5%), NNT 8.4, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Boye et al., 7/18/2021, retrospective, USA, North America, peer-reviewed, 14 authors.
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