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0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Case -44% c19early.com/mf Blanc et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Blanc, 179 patient metformin prophylaxis study: 79% lower mortality [p=0.06] and 44% more cases [p=0.12] https://c19p.org/blanc
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Therapeutic prevention of COVID-19 in elderly: a case–control study
Blanc et al., GeroScience, doi:10.1007/s11357-021-00397-z
17 Jul 2021    Source   PDF   Share   Tweet
Retrospective 179 patients in France exposed to COVID-19 showing, without statistical significance, a higher risk of cases, and a lower risk of mortality among cases with existing metformin treatment.
risk of death, 78.6% lower, RR 0.21, p = 0.06, treatment 1 of 14 (7.1%), control 25 of 75 (33.3%), NNT 3.8, COVID+.
risk of case, 43.7% higher, RR 1.44, p = 0.12, treatment 11 of 16 (68.8%), control 78 of 163 (47.9%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Blanc et al., 17 Jul 2021, retrospective, France, peer-reviewed, 22 authors.
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