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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Discharge 37% Improvement Relative Risk Recovery, D5 89% Recovery, D7, dsypnea 80% Recovery, D7, fever -3% Viral clearance, D7 24% Viral clearance, D5 5% Viral clearance, D3 12% c19early.com/aa Bhardwaja et al. Antiandrogens for COVID-19 RCT EARLY Favors antiandrogen Favors control
Bhardwaja, 76 patient antiandrogen early treatment RCT: 89% improved recovery [p=0.05] and 24% improved viral clearance [p=0.47] https://c19p.org/bhardwaja
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An integrative approach to clinical recovery for COVID-19 patients using an Ayurvedic formulation: A multicentric double-blind randomized control trial.
Bhardwaja et al., Research Square, doi:10.21203/rs.3.rs-1165680/v1 (Preprint)
27 Dec 2021    Source   PDF   Share   Tweet
Small RCT with 39 patients treated with NOQ19 and 37 placebo patients, showing improved recovery, without statistical significance. NOQ19 has multiple ingredients including curcumin and antiandrogen glycyrrhiza glabra. CTRI/2021/05/033790.
risk of no hospital discharge, 36.8% lower, RR 0.63, p = 0.67, treatment 2 of 39 (5.1%), control 3 of 37 (8.1%), NNT 34, day 7.
risk of no recovery, 89.1% lower, RR 0.11, p = 0.05, treatment 0 of 39 (0.0%), control 4 of 37 (10.8%), NNT 9.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), oxygen supplementation, day 5.
risk of no recovery, 80.4% lower, RR 0.20, p = 0.23, treatment 0 of 39 (0.0%), control 2 of 37 (5.4%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 7, dsypnea.
risk of no recovery, 2.8% higher, RR 1.03, p = 1.00, treatment 13 of 39 (33.3%), control 12 of 37 (32.4%), day 7, fever.
risk of no viral clearance, 24.1% lower, RR 0.76, p = 0.47, treatment 12 of 39 (30.8%), control 15 of 37 (40.5%), NNT 10, day 7.
risk of no viral clearance, 5.1% lower, RR 0.95, p = 1.00, treatment 19 of 39 (48.7%), control 19 of 37 (51.4%), NNT 38, day 5.
risk of no viral clearance, 12.4% lower, RR 0.88, p = 0.47, treatment 24 of 39 (61.5%), control 26 of 37 (70.3%), NNT 11, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Bhardwaja et al., 27 Dec 2021, Double Blind Randomized Controlled Trial, India, preprint, 26 authors, this trial uses multiple treatments in the treatment arm (combined with 18 other ingredients) - results of individual treatments may vary.
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