Bennani, 118 patient various antiandrogen prophylaxis study: 95% lower mortality [p=1], 119% higher ICU admission [p=0.4], 25% lower hospitalization [p=0.6], and 8% lower severe cases [p=1] https://c19p.org/bennani
copied to clipboard
Androgen deprivation therapy may constitute a more effective COVID-19 prophylactic than therapeutic strategy
et al., Annals of Oncology, doi:10.1016/j.annonc.2020.08.2095
Retrospective 118 prostate cancer patients, 4 on androgren deprivation therapy, not showing significant differences (as expected with only 4 patients in the treatment group).
|
risk of death, 94.9% lower, RR 0.05, p = 1.00, treatment 0 of 4 (0.0%), control 18 of 114 (15.8%), NNT 6.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
|
|
risk of ICU admission, 119.2% higher, RR 2.19, p = 0.40, treatment 1 of 4 (25.0%), control 13 of 114 (11.4%).
|
|
risk of hospitalization, 25.0% lower, RR 0.75, p = 0.60, treatment 2 of 4 (50.0%), control 76 of 114 (66.7%), NNT 6.0.
|
|
risk of severe case, 8.1% lower, RR 0.92, p = 1.00, treatment 1 of 4 (25.0%), control 31 of 114 (27.2%), NNT 46.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Bennani et al., 8/17/2020, retrospective, Italy, Europe, peer-reviewed, 2 authors.
Please send us corrections, updates, or comments. Vaccines and
treatments are both valuable and complementary. All practical, effective, and
safe means should be used. No treatment, vaccine, or intervention is 100%
available and effective for all current and future variants. Denying the
efficacy of any method increases mortality, morbidity, collateral damage, and
the risk of endemic status. We do not provide medical advice. Before taking
any medication, consult a qualified physician who can provide personalized
advice and details of risks and benefits based on your medical history and
situation. FLCCC and WCH
provide treatment protocols.