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Antiandrogen study #3   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 95% Imp. Relative Risk, 95% CI ICU admission -119% Hospitalization 25% Severe case 8% Bennani: Androgen deprivation therapy may constitute a more effec.. c19early.com/bennani.html Favors antiandrogen Favors control
8/17 Prophylaxis study
Bennani et al., Annals of Oncology, doi:10.1016/j.annonc.2020.08.2095 (Peer Reviewed)
Androgen deprivation therapy may constitute a more effective COVID-19 prophylactic than therapeutic strategy
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Retrospective 118 prostate cancer patients, 4 on androgren deprivation therapy, not showing significant differences (as expected with only 4 patients in the treatment group).
risk of death, 94.9% lower, RR 0.05, p = 1.00, treatment 0 of 4 (0.0%), control 18 of 114 (15.8%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 119.2% higher, RR 2.19, p = 0.40, treatment 1 of 4 (25.0%), control 13 of 114 (11.4%).
risk of hospitalization, 25.0% lower, RR 0.75, p = 0.60, treatment 2 of 4 (50.0%), control 76 of 114 (66.7%).
risk of severe case, 8.1% lower, RR 0.92, p = 1.00, treatment 1 of 4 (25.0%), control 31 of 114 (27.2%).
Bennani et al., 8/17/2020, retrospective, Italy, Europe, peer-reviewed, 2 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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