Bennani, 118 patient various antiandrogen prophylaxis study: 95% lower mortality [p=1], 119% higher ICU admission [p=0.4], 25% lower hospitalization [p=0.6], and 8% lower severe cases [p=1] https://c19p.org/bennani
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Androgen deprivation therapy may constitute a more effective COVID-19 prophylactic than therapeutic strategy
et al., Annals of Oncology, doi:10.1016/j.annonc.2020.08.2095
Retrospective 118 prostate cancer patients, 4 on androgren deprivation therapy, not showing significant differences (as expected with only 4 patients in the treatment group).
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risk of death, 94.9% lower, RR 0.05, p = 1.00, treatment 0 of 4 (0.0%), control 18 of 114 (15.8%), NNT 6.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of ICU admission, 119.2% higher, RR 2.19, p = 0.40, treatment 1 of 4 (25.0%), control 13 of 114 (11.4%).
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risk of hospitalization, 25.0% lower, RR 0.75, p = 0.60, treatment 2 of 4 (50.0%), control 76 of 114 (66.7%), NNT 6.0.
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risk of severe case, 8.1% lower, RR 0.92, p = 1.00, treatment 1 of 4 (25.0%), control 31 of 114 (27.2%), NNT 46.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Bennani et al., 17 Aug 2020, retrospective, Italy, peer-reviewed, 2 authors.
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