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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 55% Improvement Relative Risk Ventilation time 49% ICU time 44% Hospitalization time 26% c19early.com/aa Barnette et al. Sabizabulin for COVID-19 RCT LATE Favors sabizabulin Favors control
Barnette, 150 patient sabizabulin antiandrogen late treatment RCT: 55% lower mortality [p=0.002], 49% shorter ventilation [p=0.001], 44% shorter ICU admission [p=0.001], and 26% shorter hospitalization [p=0.03] https://c19p.org/barnette
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Oral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis
Barnette et al., NEJM Evidence, doi:10.1056/EVIDoa2200145
6 Jul 2022    Source   PDF   Share   Tweet
RCT with 98 hospitalized moderate/severe patients treated with sabizabulin and 52 control patients, showing lower mortality with treatment. Sabizabulin 9mg for up to 21 days. For more discussion see [twitter.com, twitter.com (B), twitter.com (C)].
risk of death, 55.2% lower, RR 0.45, p = 0.002, treatment 19 of 94 (20.2%), control 23 of 51 (45.1%), NNT 4.0.
ventilation time, 49.5% lower, relative time 0.51, p = 0.001, treatment 98, control 52.
ICU time, 43.5% lower, relative time 0.56, p = 0.001, treatment 98, control 52.
hospitalization time, 26.0% lower, relative time 0.74, p = 0.03, treatment 98, control 52.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Barnette et al., 7/6/2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, 12 authors, study period 18 May, 2021 - 31 January, 2022.
Contact: gbarnette@verupharma.com.
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Late treatment
is less effective
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