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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 17% Improvement Relative Risk Recovery 6% Recovery, day 5 -8% Discharge 7% Ensovibep  ACTIV-3/TICO  LATE TREATMENT  DB RCT Is late treatment with ensovibep beneficial for COVID-19? Double-blind RCT 485 patients in multiple countries (Jun - Nov 2021) Lower mortality with ensovibep (not stat. sig., p=0.46) c19early.org Barkauskas et al., Annals of Internal .., Aug 2022 Favors ensovibep Favors control

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19

Barkauskas et al., Annals of Internal Medicine, doi:10.7326/M22-1503, ACTIV-3/TICO, NCT04501978
Aug 2022  
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RCT 485 hospitalized patients showing no significant differences with ensovibep treatment. Intravenous ensovibep, 600mg.
risk of death, 17.0% lower, HR 0.83, p = 0.46, treatment 30 of 247 (12.1%), control 35 of 238 (14.7%), NNT 39, Kaplan–Meier, day 90.
risk of no recovery, 5.7% lower, HR 0.94, p = 0.55, treatment 44 of 247 (17.8%), control 48 of 238 (20.2%), NNT 42, adjusted per study, inverted to make HR<1 favor treatment.
risk of no recovery, 7.5% higher, HR 1.08, p = 0.68, treatment 247, control 238, adjusted per study, inverted to make HR<1 favor treatment, pulmonary ordinal outcome, day 5.
risk of no hospital discharge, 6.5% lower, HR 0.93, p = 0.46, treatment 28 of 247 (11.3%), control 34 of 238 (14.3%), adjusted per study, inverted to make HR<1 favor treatment.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Barkauskas et al., 9 Aug 2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, 80 authors, study period 11 June, 2021 - 15 November, 2021, average treatment delay 8.0 days, trial NCT04501978 (history) (ACTIV-3/TICO).
This PaperEnsovibepAll
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19
Christina Barkauskas, Eleftherios Mylonakis, Garyfallia Poulakou, Barnaby E Young, David M Vock, Lianne Siegel, Nicole Engen, Greg Grandits, Nilima R Mosaly, Andrew M Vekstein, Ralph Rogers, Fadi Shehadeh, Matthew Kaczynski, Evangelia K Mylona, Konstantinos N Syrigos, Vasiliki Rapti, David C Lye, Diong Shiau Hui, Lindsay Leither, Kirk U Knowlton, Mamta K Jain, Rubria Marines-Price, Alice Osuji, J Scott Overcash, Ioannis Kalomenidis, Zafeiria Barmparessou, Michael Waters, Karla Zepeda, Peter Chen, Sam Torbati, Francis Kiweewa, Nicholus Sebudde, Eyad Almasri, Alyssa Hughes, Sanjay R Bhagani, Alison Rodger, Uriel Sandkovsky, Robert L Gottlieb, Eriobu Nnakelu, Barbara Trautner, Vidya Menon, Joseph Lutaakome, Michael Matthay, Philip Robinson, Konstantinos Protopapas, Nikolaos Koulouris, Ivan Kimuli, Amiran Baduashvili, Dominique L Braun, Huldrych F Günthard, Srikanth Ramachandruni, Robert Kidega, Kami Kim, Timothy J Hatlen, Andrew N Phillips, Daniel D Murray, Tomas O Jensen, Maria L Padilla, Evan X Accardi, Katy Shaw-Saliba, Robin L Dewar, Marc Teitelbaum, Ven Natarajan, Sylvain Laverdure, Helene C Highbarger, M Tauseef Rehman, Susan Vogel, David Vallée, Page Crew, Negin Atri, Adam J Schechner, Sarah Pett, Fleur Hudson, Jonathan Badrock, Giota Touloumi, Samuel M Brown, Wesley H Self, Crystal M North, Adit A Ginde, Christina C Chang, Anthony Kelleher, Stephanie Nagy-Agren, Shikha Vasudeva, David Looney, Hien H Nguyen, Adriana Sánchez, Amy C Weintrob, Birgit Grund, Shweta Sharma, Cavan S Reilly, Roger Paredes, Agnieszka Bednarska, Norman P Gerry, Abdel G Babiker, Victoria J Davey, Annetine C Gelijns, Elizabeth S Higgs, Virginia Kan, Gail Matthews, B Taylor Thompson, Philippe Legenne, Richa Chandra, H Clifford Lane, James D Neaton, Jens D Lundgren, Christina Barkauskas, Eleftherios Mylonakis, Garyfallia Poulakou, Barnaby E Young, David M Vock, Lianne Siegel, Nicole Engen, Greg Grandits, Nilima R Mosaly, Andrew M Vekstein, Ralph Rogers, Fadi Shehadeh, Matthew Kaczynski, Evangelia K Mylona, Konstantinos N Syrigos, Vasiliki Rapti, David C Lye, Diong Shiau Hui, Lindsay Leither, Kirk U Knowlton, Mamta K Jain, Rubria Marines-Price, Alice Osuji, J Scott Overcash, Ioannis Kalomenidis, Zafeiria Barmparessou, Michael Waters, Karla Zepeda, Peter Chen, Sam Torbati, Francis Kiweewa, Nicholus Sebudde, Eyad Almasri, Alyssa Hughes, Sanjay R Bhagani, Alison Rodger, Uriel Sandkovsky, Robert L Gottlieb, Eriobu Nnakelu, Barbara Trautner, Vidya Menon, Joseph Lutaakome, Michael Matthay, Philip Robinson, Konstantinos Protopapas, Nikolaos Koulouris, Ivan Kimuli, Amiran Baduashvili, Dominique L Braun, Huldrych F Günthard, Srikanth Ramachandruni, Robert Kidega, Kami Kim, Timothy J Hatlen, Andrew N Phillips, Daniel D Murray, Tomas O Jensen, Maria L Padilla, Evan X Accardi, Katy Shaw-Saliba, Robin L Dewar, Marc Teitelbaum, Ven Natarajan, Sylvain Laverdure, Helene C Highbarger, M Tauseef Rehman, Susan Vogel, David Vallée, Page Crew, Negin Atri, Adam J Schechner, Sarah Pett, Fleur Hudson, Jonathan Badrock, Giota Touloumi, Samuel M Brown, Wesley H Self, Crystal M North, Adit A Ginde, Christina C Chang, Anthony Kelleher, Stephanie Nagy-Agren, Shikha Vasudeva, David Looney, Hien H Nguyen, Adriana Sánchez, Amy C Weintrob, Birgit Grund, Shweta Sharma, Cavan S Reilly, Roger Paredes, Agnieszka Bednarska, Norman P Gerry, Abdel G Babiker, Victoria J Davey, Annetine C Gelijns, Elizabeth S Higgs, Virginia Kan, Gail Matthews, B Taylor Thompson, Philippe Legenne, Richa Chandra, H Clifford Lane, James D Neaton, Jens D Lundgren, David Sahner, John Tierney, Betsey R Herpin, Mary C Smolskis, Laura A Mckay, Kelly Cahill, Ratna Sardana, Sharon Segal Raim, Lisa Hensely, Joshua Lorenzo, Rebecca Mock, Judith Zuckerman, Mark Miller, Lucy Chung, Nayon Kang, Stacey J Adam, Sarah Read, Ruxandra Draghia-Akli, Amy Carlsen, Anita Carter, Eileen Denning, Alain Duchene, Kate Eckroth, Alex Frase, Greg Gandits, Merrie Harrison, Payton Kaiser, Joseph Koopmeiners, Sue Meger, Thomas Murray, Kien Quan, Siu Fun Quan, Greg Thompson, Jamie Walski, Deborah Wentworth, Alan J Moskowitz, Emilia Bagiella, Ellen Moquete, Karen O’sullivan, Mary E Marks
Annals of Internal Medicine, doi:10.7326/m22-1503
Background: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. Objective: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared with standard care alone.
Author contributions are available at Annals.org.
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Lundgren, Drs, Barkauskas, Mylonakis, and Young contributed equally to this work
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Late treatment
is less effective
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