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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 69% Improvement Relative Risk Mechanical ventilation 77% ICU admission 77% Hospitalization time 15% c19early.com/avdeev.html Favors N-acetylcysteine Favors control
9 July 2021 - Late treatment study
N-acetylcysteine for the treatment of COVID-19 among hospitalized patients
Avdeev et al., Journal of Infection, doi:10.1016/j.jinf.2021.07.003 (Peer Reviewed)
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Prospective study of 24 hospitalized COVID-19 patients in Russia treated with NAC, and 22 matched controls, showing significantly improved SpO2/FiO2, and significantly shorter hospitalization with treatment.
risk of death, 69.4% lower, RR 0.31, p = 0.34, treatment 1 of 24 (4.2%), control 3 of 22 (13.6%), NNT 11.
risk of mechanical ventilation, 77.1% lower, RR 0.23, p = 0.18, treatment 1 of 24 (4.2%), control 4 of 22 (18.2%), NNT 7.1.
risk of ICU admission, 77.1% lower, RR 0.23, p = 0.18, treatment 1 of 24 (4.2%), control 4 of 22 (18.2%), NNT 7.1.
hospitalization time, 15.4% lower, relative time 0.85, p = 0.01, treatment 24, control 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Avdeev et al., 7/9/2021, retrospective, Russia, Europe, peer-reviewed, 4 authors, study period 12 April, 2020 - 20 June, 2020, average treatment delay 7.2 days.
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