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Home   COVID-19 treatment studies for Remdesivir  COVID-19 treatment studies for Remdesivir  C19 studies: Remdesivir  Remdesivir   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality 20% Improvement Relative Risk Mortality (b) 18% Ventilation -68% c19early.com/s Arch et al. Remdesivir for COVID-19 LATE TREATMENT Favors remdesivir Favors control
Arch, 6,230 patient remdesivir late treatment PSM study: 20% lower mortality [p=0.03] and 68% higher ventilation [p=0.003] https://c19p.org/arch
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Evaluation of the effectiveness of remdesivir in treating severe COVID-19 using data from the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, national cohort study
Arch et al., medRxiv, doi:10.1101/2021.06.18.21259072 (Preprint)
21 Jun 2021    Source   PDF   Share   Tweet
Prospective PSM analysis of remdesivir use in the UK showing statistically significantly lower mortality at 28 days. For unspecified reasons, the study prioritized short-term outcomes. Mortality at 14 days was also lower but not statistically significant. Confounding by indication is likely and may only be partially addressed by the variables included in the PSM.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 19.9% lower, RR 0.80, p = 0.03, treatment 203 of 1,491 (13.6%), control 777 of 4,676 (16.6%), NNT 33, odds ratio converted to relative risk, 28 days, PSM.
risk of death, 18.0% lower, RR 0.82, p = 0.12, treatment 140 of 1,502 (9.3%), control 565 of 4,728 (12.0%), NNT 38, odds ratio converted to relative risk, 28 days, PSM.
risk of mechanical ventilation, 68.0% higher, RR 1.68, p = 0.003, treatment 106 of 1,498 (7.1%), control 153 of 4,602 (3.3%), odds ratio converted to relative risk, 28 days, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arch et al., 21 Jun 2021, prospective, propensity score matching, United Kingdom, preprint, 10 authors, average treatment delay 6.0 days.
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This PaperRemdesivirAll
Late treatment
is less effective
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