Arbel, 109,213 patient paxlovid early treatment study: 81% lower mortality [p=0.02] and 67% lower hospitalization [p<0.0001] https://c19p.org/arbel
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Oral Nirmatrelvir and Severe Covid-19 Outcomes During the Omicron Surge
et al., Research Square, doi:10.21203/rs.3.rs-1705061/v1 (Preprint)
Retrospective 109,213 patients in Israel, 3,939 treated with nirmatrelvir, showing lower mortality and hospitalization with treatment for the subgroup of patients >65. Authors only provide subgroup results.
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risk of death, 81.0% lower, HR 0.19, p = 0.02, treatment 14 of 2,504 (0.6%), control 762 of 40,315 (1.9%), adjusted per study, multivariable, Cox proportional hazards, age 65+.
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risk of death, 64.0% higher, HR 1.64, p = 0.59, treatment 9 of 1,435 (0.6%), control 334 of 64,959 (0.5%), adjusted per study, multivariable, Cox proportional hazards, age 40-64.
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risk of hospitalization, 67.0% lower, HR 0.33, p < 0.001, treatment 2 of 2,504 (0.1%), control 151 of 40,315 (0.4%), adjusted per study, multivariable, Cox proportional hazards, age 65+.
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risk of hospitalization, 22.0% lower, HR 0.78, p = 0.48, treatment 1 of 1,435 (0.1%), control 13 of 64,959 (0.0%), adjusted per study, multivariable, Cox proportional hazards, age 40-64.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Arbel et al., 6/1/2022, retrospective, Israel, Middle East, preprint, mean age 60.0, 12 authors.
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