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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 91% Improvement Relative Risk Ventilation 89% ICU admission 82% c19early.com/b Ansarin et al. Bromhexine for COVID-19 RCT EARLY TREATMENT Favors bromhexine Favors control
Ansarin, 78 patient bromhexine early treatment RCT: 91% lower mortality [p=0.05], 89% lower ventilation [p=0.01], and 82% lower ICU admission [p=0.01] https://c19p.org/ansarin
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Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial
Ansarin et al., Bioimpacts, doi:10.34172/bi.2020.27
19 Jul 2020    Source   PDF   Share   Tweet
RCT with 39 bromhexine and 39 control patients showing lower mortality, intubation, and ICU admission with treatment. The treatment group received bromhexine hydrochloride 8 mg three times a day for two weeks. All patients received SOC including HCQ.
Bromhexine may be less effective for omicron due to the entry process moving towards TMPRSS2-independent fusion.
risk of death, 90.9% lower, RR 0.09, p = 0.05, treatment 0 of 39 (0.0%), control 5 of 39 (12.8%), NNT 7.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 88.9% lower, RR 0.11, p = 0.01, treatment 1 of 39 (2.6%), control 9 of 39 (23.1%), NNT 4.9.
risk of ICU admission, 81.8% lower, RR 0.18, p = 0.01, treatment 2 of 39 (5.1%), control 11 of 39 (28.2%), NNT 4.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ansarin et al., 19 Jul 2020, Randomized Controlled Trial, Iran, peer-reviewed, 11 authors.
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