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0 0.5 1 1.5 2+ Hospitalization 80% Improvement Relative Risk Recovery 83% c19early.com/altay.html Favors N-acetylcysteine Favors control
28 June 2021 - Early treatment study
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
Altay et al., Advanced Science, doi:10.1002/advs.202101222 (Peer Reviewed)
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RCT 304 low-risk outpatients, 229 treated with N-acetylcysteine, l-carnitine tartrate, nicotinamide riboside chloride, and serine, showing significantly faster recovery with treatment. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism were significantly improved in treated patients.
risk of hospitalization, 80.1% lower, RR 0.20, p = 0.25, treatment 0 of 229 (0.0%), control 1 of 76 (1.3%), NNT 76, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no recovery, 82.7% lower, RR 0.17, p < 0.001, treatment 229, control 75, multivariate Cox regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Altay et al., 6/28/2021, Double Blind Randomized Controlled Trial, placebo-controlled, Turkey, Europe, peer-reviewed, 18 authors, this trial uses multiple treatments in the treatment arm (combined with l-carnitine tartrate, nicotinamide riboside chloride, serine) - results of individual treatments may vary.
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