Treatment and prophylaxis studies of vitamin A in Iraq.
The treatment study contained 100 patients, 50 treated with 200,000IU vitamin A for two days, showing lower progression to severe disease, and shorter duration of symptoms.
The prophylaxis study contained 209 contacts of COVID-19 patients, 97 treated with vitamin A, showing significantly lower cases with treatment, and shorter duration of symptoms.
Al-Sumiadai et al., 1/31/2021, prospective, Iraq, Middle East, preprint, 3 authors.
risk of disease progression, 66.7% lower, RR 0.33, p = 0.27, treatment 2 of 50 (4.0%), control 6 of 50 (12.0%), progression to severe disease.
recovery time, 37.5% lower, relative time 0.62, treatment 50, control 50.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.