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0 0.5 1 1.5 2+ Death/ICU 55% Improvement Relative Risk Death/ICU (b) -68% c19early.com/mf Al-Salameh et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Al-Salameh, 97 patient metformin prophylaxis study: 55% lower combined mortality/ICU admission [p=0.04] https://c19p.org/alsalameh
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The association between metformin treatment and COVID-19 outcomes according to metformin continuation during hospitalisation
Al-Salameh et al., Diabetes & Metabolism, doi:10.1016/j.diabet.2021.101297
30 Nov 2021    Source   PDF   Share   Tweet
Retrospective 140 diabetic patients in France, showing lower mortality for patients where metformin use was continued after hospitalization.
risk of death/ICU, 55.5% lower, RR 0.45, p = 0.04, treatment 9 of 47 (19.1%), control 22 of 50 (44.0%), NNT 4.0, adjusted per study, odds ratio converted to relative risk, metformin continued, multivariable.
risk of death/ICU, 68.4% higher, RR 1.68, p = 0.02, treatment 34 of 43 (79.1%), control 22 of 50 (44.0%), adjusted per study, odds ratio converted to relative risk, metformin discontinued, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Salameh et al., 11/30/2021, retrospective, France, Europe, peer-reviewed, 4 authors.
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