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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 89% Improvement Relative Risk Hospitalization 62% c19sv.com Aggarwal et al. Sotrovimab for COVID-19 EARLY Favors sotrovimab Favors control
Aggarwal, 2,085 patient sotrovimab early treatment PSM study: 89% lower mortality [p=0.05] and 62% lower hospitalization [p=0.002] https://c19p.org/aggarwal
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Real-World Evidence of the Neutralizing Monoclonal Antibody Sotrovimab for Preventing Hospitalization and Mortality in COVID-19 Outpatients
Aggarwal et al., medRxiv, doi:10.1101/2022.04.03.22273360 (Preprint)
5 Apr 2022    Source   PDF   Share   Tweet
Retrospective 522 sotrovimab patients and matched controls in the USA, showing significantly lower hospitalization and mortality with treatment.
Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.1 [Liu, Sheward, VanBlargan] and a lack of efficacy for BA.2 [Zhou]. US EUA has been revoked.
risk of death, 88.9% lower, RR 0.11, p = 0.048, treatment 0 of 522 (0.0%), control 15 of 1,563 (1.0%), NNT 104, adjusted per study, odds ratio converted to relative risk, propensity score matching, multivariable, day 28.
risk of hospitalization, 61.6% lower, RR 0.38, p = 0.002, treatment 11 of 522 (2.1%), control 89 of 1,563 (5.7%), NNT 28, adjusted per study, odds ratio converted to relative risk, propensity score matching, multivariable, day 28.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Aggarwal et al., 5 Apr 2022, retrospective, USA, preprint, 14 authors, study period 1 October, 2021 - 11 December, 2021.
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