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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality -100% Improvement Relative Risk c19ly.com ACTIV-3/TICO et al. NCT04501978 Bamlaniv../e.. RCT LATE Favors bamlanivimab/e.. Favors control
ACTIV-3/TICO, 314 patient bamlanivimab/etesevimab late treatment RCT: 100% higher mortality [p=0.22] https://c19p.org/activ3
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A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
ACTIV-3/TICO LY-CoV555 study group, NEJM, doi:0.1056/NEJMoa2033130, ACTIV-3, NCT04501978 (history)
22 Dec 2020    Source   PDF   Share   Tweet
Late stage RCT of LY-CoV555 added to remdesivir, showing non-statistically significant higher mortality with the addition of LY-CoV555.
Efficacy is highly variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, VanBlargan].
risk of death, 100% higher, HR 2.00, p = 0.22, treatment 9 of 163 (5.5%), control 5 of 151 (3.3%), adjusted per study, proportional hazards regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
ACTIV-3/TICO et al., 22 Dec 2020, Randomized Controlled Trial, USA, peer-reviewed, 1 author, average treatment delay 7.0 days, trial NCT04501978 (history) (ACTIV-3).
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This PaperBamlaniv../e..All
Late treatment
is less effective
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